Teledyne ISCO CombiFlash Rf flash chromatography system.

The Teledyne ISCO CombiFlash Rf is an automated flash chromatography system designed for the separation and purification of chemical compounds in research and development laboratories. Manufactured by Teledyne ISCO, the system is used in organic chemistry, pharmaceutical research, biotechnology, natural product isolation, and analytical chemistry. It automates important stages of flash chromatography, helping researchers separate mixtures into individual fractions more efficiently than conventional manual column chromatography.

Flash chromatography is a liquid chromatography technique in which a sample passes through a packed column containing a stationary phase, commonly silica-based media. Different compounds interact with the stationary phase to different degrees and therefore travel through the column at different rates. The resulting separation allows researchers to collect fractions containing the compounds of interest.

The CombiFlash Rf integrates key chromatography functions into a single instrument. Depending on the model configuration, these can include solvent delivery, programmable solvent gradients, ultraviolet (UV) detection, and automated fraction collection. The system can help users develop purification methods, monitor compound separation, and collect fractions for subsequent analysis or experimental use.

The instrument shown in the photograph features a large front display, a dedicated control interface, an upper sample and solvent handling area, and a lower collection area. Its integrated design is intended to organize the chromatography workflow in a compact laboratory footprint. The exact detector, pump configuration, collection rack, and accessories supplied with this particular instrument should be verified before purchase.

A major advantage of automated flash chromatography is the ability to control solvent composition during a purification run. Gradient elution allows the solvent strength to change according to a programmed method, which can improve separation for mixtures containing compounds with different retention characteristics. Compatible CombiFlash Rf systems support programmable gradients and online UV monitoring, although exact capabilities depend on the model and installed options.

The CombiFlash Rf product family has been used for purification in drug discovery, natural products research, agrochemicals, petrochemicals, polymers, and catalyst research. Pharmaceutical and chemical laboratories can use flash chromatography to isolate intermediates, purify synthesized compounds, and prepare materials for further analytical characterization.

For research institutions and laboratories maintaining existing chromatography equipment, a used CombiFlash Rf system may provide a practical option for routine compound purification. Before purchasing, buyers should confirm the instrument's precise model, pressure rating, solvent flow range, detector configuration, fraction collector functionality, software availability, and compatibility with the required columns.

Because the pictured instrument appears to be an earlier CombiFlash Rf generation, newer-model specifications should not automatically be applied to it. The correct technical information should be established using the manufacturer's identification label and model-specific documentation.

2.2 Applications of the Product

• Pharmaceutical research: Purification of compounds and intermediates during drug discovery.

• Organic synthesis: Separation of reaction mixtures and isolation of synthesized products.

• Natural product research: Purification of compounds extracted from plants and other natural materials.

• Chemical research and development: Separation and recovery of target compounds.

• Biotechnology laboratories: Purification of suitable research chemicals and biomolecules where compatible.

• Agrochemical research: Purification of compounds investigated for agricultural applications.

• Polymer and catalyst research: Separation and purification of appropriate chemical materials.

• Academic laboratories: Training and experimental research involving chromatographic separation.

• Method development: Evaluation of solvent gradients and purification conditions for compound mixtures.

2.3 Features of the Product

• Automated flash chromatography workflow.

• Programmable solvent-gradient capability on compatible configurations.

• Integrated instrument control interface.

• Large front display for operation and monitoring.

• Online UV detection on appropriately equipped configurations.

• Automated fraction collection on compatible systems.

• Compatibility with suitable flash chromatography columns.

• Support for normal-phase and reversed-phase purification, depending on the configuration and solvent system.

• Integrated design for laboratory benchtop use.

• Suitable for chemical purification and research applications.

2.4 Technical Specifications

2.5 Product Condition

Choose the appropriate condition for your listing:

• Refurbished: Inspected, serviced as required, and functionally tested.

• Used: Pre-owned equipment sold in its existing condition.

• Brand new: Unused equipment with new-product status verified.

For a used system, test the solvent pumps, fluid connections, detector, fraction collector, display, control software, and safety functions before making operational claims.