The MicroCal VP-DSC MicroCalorimeter is a high-sensitivity Differential Scanning Calorimeter (DSC) designed for studying the thermal stability and thermodynamic properties of biological macromolecules and other samples in solution. The unit shown in the photograph is clearly marked VP-DSC MicroCalorimeter and features the MicroCal branding with an illuminated POWER indicator.

The VP-DSC directly measures heat-capacity changes associated with temperature-induced transitions in sample and reference solutions. It can provide information such as transition temperature (Tm), enthalpy (ΔH), entropy (ΔS) and heat-capacity change (ΔCp), making it particularly useful for protein and biomolecular stability research. Malvern Panalytical

The original VP-DSC specification lists a −10 °C to 130 °C operating temperature range, fixed tantalum sample/reference cells with approximately 0.5 mL effective cell volume, a minimum response time of approximately 7 seconds and user-selectable temperature scan rates. Malvern Panalytical

The photographed unit is a previously used instrument. The front POWER indicator is illuminated, but complete measurement performance, cell condition, temperature calibration and software/interface functionality should be verified before analytical use.

Applications

The MicroCal VP-DSC is suitable for protein stability and folding studies, including investigation of thermal denaturation and conformational transitions. It can also be applied to nucleic acids, lipid and membrane systems, micelles and other structured macromolecules in solution. Malvern Panalytical

The instrument can support pharmaceutical and biotechnology research, protein engineering, formulation development, process-development studies and investigation of the effects of structural changes or ligand interactions on biomolecular stability. Institute of Information Science

Main Features

• MicroCal VP-DSC MicroCalorimeter
• Differential Scanning Calorimetry technology
• High-sensitivity calorimetric measurement
• Fixed tantalum sample and reference cells
• Approximately 0.5 mL cell volume
• −10 °C to 130 °C operating temperature range
• User-selectable temperature scan rates
• Upscan and downscan operation
• Peltier-based temperature control
• Self-contained pressurization capability
• Designed for biomolecular thermal-stability studies

Technical Specifications

The VP-DSC specifications above are based on the MicroCal VP-DSC documentation and manufacturer support information. Malvern Panalytical

Benefits of Refurbished Laboratory Equipment

A refurbished MicroCal VP-DSC can provide laboratories with access to advanced differential scanning calorimetry capabilities at a lower acquisition cost than purchasing a new instrument. It can be particularly useful for research laboratories working with proteins, nucleic acids, pharmaceutical formulations, membranes and other biomolecular systems.

Legacy analytical instruments can also be valuable when laboratories already have compatible accessories, software workflows or established experimental protocols. Before purchase, the instrument should be evaluated for calorimetric sensitivity, baseline stability, temperature accuracy, cell condition, pressure system operation and software compatibility.

Additional Information

The photographed unit is identified as a MicroCal VP-DSC MicroCalorimeter. The complete VP-DSC system can include the calorimeter assembly, controller/monitor electronics, software and sample-preparation/cleaning accessories. The availability of these components should be confirmed with the supplied unit.

The photograph shows the main instrument housing with the POWER indicator illuminated. However, a powered indicator alone does not confirm calorimetric performance. The fixed sample and reference cells are critical components and should be inspected and tested before use. The VP-DSC cells are fixed in place and non-removable, according to the manufacturer's documentation. Malvern Panalytical

• Malvern Panalytical – MicroCal VP-DSC
• MicroCal VP-DSC Technical Information
• MicroCal VP-DSC User Manual

Refurbished Condition

This is a refurbished MicroCal VP-DSC MicroCalorimeter. The instrument has been professionally inspected and tested. Reagents, accessories, software and consumables may vary depending on availability.